Holger Wille

This paper demonstrates that delivering a protective prion protein variant via gene therapy extends survival in a prion disease mouse model.

This paper designs vaccines targeting misfolded alpha-synuclein by mimicking its fibril structure, inducing antibodies that recognize pathological forms without reacting to native protein.

This study identifies fibronectin as a natural barrier against prion infection by showing its association with PrPSc and its ability to reduce prion infectivity in vitro and in tissues.

This study shows that somatostatin reduces Aβ plaque formation in aged mice by inhibiting Aβ aggregation, independent of neprilysin.

This study shows that post-traumatic seizures and dynamin-dependent endocytosis promote tauopathy spread after TBI using a zebrafish model.

This study shows that lowering prion protein expression with ASOs is effective in treating prion disease across different strains, treatment times, and endpoints.