Judd M. Aiken

This study identifies fibronectin as a natural barrier against prion infection by showing its association with PrPSc and its ability to reduce prion infectivity in vitro and in tissues.

This study uses nanopore sequencing to show that mtDNA deletion mutations increase exponentially with age and map to a wider genomic region, with novel algorithms improving detection accuracy.

This study investigates the effects of remdesivir on mitochondrial DNA in aged rats and finds no significant changes in copy number or deletion mutation frequency.

This study shows that lowering prion protein expression with ASOs is effective in treating prion disease across different strains, treatment times, and endpoints.