Yuan‐Chen Tsai

This paper introduces a hydrogel platform to spatially engineer posterior signaling centers in cerebral organoids through controlled morphogen exposure, improving spatial organization and cellular diversity.

This study develops a method to generate neocortical organoids with distinct anterior-posterior molecular signatures and uses them to model Fragile X Syndrome pathology.

This paper introduces a Brain Organoid-on-a-Chip platform that generates signaling gradients to create topographic forebrain organoids, mimicking human brain regions for neurodevelopment and disease studies.

This study investigates how splice isoforms of collybistin (CB1 and CB2) regulate neuronal maturation and synapse formation through their effects on Cdc42 and GABAAR signaling in the developing brain.