Hajime Ozaki

This paper introduces a hydrogel platform to spatially engineer posterior signaling centers in cerebral organoids through controlled morphogen exposure, improving spatial organization and cellular diversity.

This study develops a method to generate neocortical organoids with distinct anterior-posterior molecular signatures and uses them to model Fragile X Syndrome pathology.

This paper introduces a Brain Organoid-on-a-Chip platform that generates signaling gradients to create topographic forebrain organoids, mimicking human brain regions for neurodevelopment and disease studies.