BioengineeringScience Translational MedicinePeer-reviewed
CRISPR-Cas9 Engineered Extracellular Vesicles for the Treatment of Dominant Progressive Hearing Loss
Xiaoshu Pan, Peixin Huang, Samantha Ali…·Mei He
The paper develops a scalable microfluidic electroporation system to load gRNA:Cas9 RNP complexes into extracellular vesicles, achieving effective gene therapy for hearing loss in a mouse model.
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