Cancer BiologyNature CommunicationsPeer-reviewed
ASPSCR1-TFE3 reprograms transcription by organizing enhancer loops around hexameric VCP/p97
Amir Pozner, Li Li, Shiv Prakash Verma…·Kevin B. Jones
This study identifies VCP/p97 as an obligate co-factor of ASPSCR1-TFE3, showing it organizes enhancer loops to drive oncogenic transcription in ASPS and RCC.