Douglas J. Mahoney

This paper introduces PRIME-VLP, a delivery strategy that enhances prime editing efficiency for genome engineering and high-throughput screening using eVLPs.

This study identifies microbiome-derived hydroxyphenyl propanoates (HPPs) that enhance antitumour immunity by boosting gasdermin D activity in myeloid cells, improving immune checkpoint therapy outcomes in mice and correlating with better responses in human melanoma patients.

The paper identifies CELF2 variants causing cytoplasmic mislocalization linked to neuronal hyperexcitability, learning deficits, and seizures.

The paper uses a novel computational workflow to analyze a spatiotemporally profiled GBM xenograft cohort, identifying 15 tumor cell programs related to invasion and their prognostic significance in GBM patients.