Author
Mark Perelis
Ionis Pharmaceuticals (United States)ORCID 0000-0001-5435-2552Unclaimed ORCID profile · follow to get notified of new preprints
Biology Disciplines
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2019-2025 · peak 4/yrCo-Author Collaboration Network
10 top collaborators · 11 mutual co-author links5 papers
Recent·Most cited
- PathologyProceedings of the National Academy of SciencesPeer-reviewed✦ In-depth digest
Liver lipid droplet cholesterol content is a key determinant of metabolic dysfunction-associated steatohepatitis
Ikki Sakuma, Rafael Calais Gaspar, Ali R. Nasiri…·Gerald I. Shulman
Cholesterol accumulation in hepatic lipid droplets drives inflammation and fibrosis in mouse and human MASH and is reversed by inhibiting cholesterol synthesis or knocking down Coasy or Hsd17b13.
- Cancer BiologybioRxivPreprint
Integrative CRISPR Screens and RNA-Omics Discover an Essential Role for PUF60-3' Splice Site Interactions in Cancer Progression
Alexandra T. Tankka, Jaclyn M. Einstein, Catherine J. Zhou…·Gene Wei-Ming Yeo
The paper identifies PUF60's role in cancer progression by combining CRISPR screens and RNA-omics, showing its splicing activity supports TNBC proliferation and is a potential therapeutic target.
1 citation - Cell BiologyeLifePeer-reviewed
Stratification of enterochromaffin cells by single-cell expression analysis
Yan Song, Linda J. Fothergill, Kari S. Lee…·Gene Wei-Ming Yeo
This study identifies fourteen enterochromaffin cell clusters in the gut using single-cell transcriptomics and spatial analysis, revealing subtypes with distinct functional properties and a Piezo2+ population involved in colon motility.
- Molecular BiologyCurrent BiologyPeer-reviewed
Cryptochromes-mediated Inhibition of the CRL4Cop1-Complex Assembly Defines an Evolutionary Conserved Signaling Mechanism
Luca Rizzini, Daniel C. Levine, Mark Perelis…·Michele Pagano
The paper shows mammalian Cryptochromes inhibit CRL4Cop1 complex assembly, similar to their function in plants, by interacting with Det1 to repress GR transcription.