Gerald I. Shulman

This study shows that high-fat diet reduces Usp25m in mice, impairing TUG cleavage and glucose uptake during fasting, leading to insulin resistance in skeletal muscle.

This study shows that endothelial ANGPTL4 depletion prevents diabetic kidney disease by improving metabolic function and reducing inflammation.

Cholesterol accumulation in hepatic lipid droplets drives inflammation and fibrosis in mouse and human MASH and is reversed by inhibiting cholesterol synthesis or knocking down Coasy or Hsd17b13.

This paper develops an optogenetic tool to control PKC epsilon activity with spatiotemporal precision and validates its function in phosphorylation events.

This study identifies Angptl4 as a fibrogenic molecule in diabetic kidney disease and shows that targeting its expression in kidneys reduces fibrosis and proteinuria.

This study shows that atrial AMPK deletion shifts metabolism from fatty acid oxidation to pyruvate oxidation and disrupts metabolic pathways, contributing to atrial remodeling and arrhythmia.

This study shows that hypercalcemia from tumor-secreted PTHrP activates hindbrain circuits linked to anorexia, and blocking hypercalcemia prevents these effects.