José Ordovás-Montañés

A fibroblast-CD8+ T cell circuit drives a Type 1 shift in allergic inflammatory memory

This study identifies a fibroblast-CD8+ T cell circuit that drives a Type 1 immune shift in allergic inflammatory memory through mechanistic and translational analysis in murine and human models.

Discovery Stack Pilot Demonstrates the Feasibility and Outcomes of a Scientist-Designed Peer-Review Model That Separates Quality and Impact

The paper tests a new peer-review model that separates scientific quality from impact, showing reviewers can effectively evaluate both dimensions and participants support its adoption.

Sphingosine 1-phosphate receptor-1 signaling enhances neutrophil survival while suppressing inflammation and bacterial host defense functions

This study shows that S1PR1 signaling in neutrophils enhances their survival and reduces inflammation but impairs bacterial clearance and protects against lung injury in viral infections.

Unique nasal cell states induced by common pediatric respiratory viruses

This study maps virus-specific nasal cell states in children using single-cell RNA sequencing and links them to disease severity and asthma risk.

Multi-modal choroid plexus pathology in aging and Alzheimer's disease

This study creates a multi-modal atlas of choroid plexus pathology across aging and Alzheimer's disease, identifying fibrosis, calcification, and macrophage abnormalities as key features.

Development of the Early Childhood Duodenum across Ancestry, Geography and Environment

The paper creates a cellular and spatial map of the duodenum in children, revealing environmental and developmental influences on intestinal cell states.

A niche-dependent redox rheostat regulates epithelial stem cell fate in the distal colon

This study shows that redox balance, regulated by NOX1 and HIF1-IDH1 interactions, controls epithelial stem cell fate in the distal colon niche.

A collaboration between immune cells and the choroid plexus epithelium in brain inflammation

The paper shows the ChP acts as an immune organ in brain inflammation, with immune cell interactions and epithelial cell specialization regulating the barrier.

Leveraging polygenic enrichments of gene features to predict genes underlying complex traits and diseases

The paper introduces a method to prioritize causal genes for complex traits by integrating GWAS data with gene expression and biological data, achieving high precision in gene-trait pair identification.

Robust differentiation of human enteroendocrine cells from intestinal stem cells

This study develops a method to differentiate human intestinal stem cells into functional enteroendocrine cells using small molecule targeting of specific signaling pathways.

Single-cell profiling of environmental enteropathy reveals signatures of epithelial remodeling and immune activation in severe disease

The paper uses single-cell RNA-sequencing to study environmental enteropathy, identifying epithelial and immune correlates of disease severity and suggesting new therapeutic targets.

Single-cell analysis of upper airway cells reveals host-viral dynamics in influenza infected adults

The paper uses single-cell RNA sequencing to study influenza infection in human nasal washes, identifying a novel goblet cell population and tracking viral variation across infected individuals.

Rewiring of the cellular and inter-cellular landscape of the human colon during ulcerative colitis

The paper was withdrawn due to the inclusion of confidential information about a third party.