Yousef Al‐Abed

This study shows age-dependent cholinergic deficits in the dorsal motor nucleus of the vagus in experimental Alzheimer's disease, leading to impaired vagus nerve function.

This study characterizes longitudinal vagus nerve activity in mice over weeks, showing changes in compound action potentials under anesthesia and during wakefulness.

This study evaluates four peptide backbone modifications to enhance stability while preserving function, finding that azapeptides maintain activity and offer improved stability.

This study shows endogenous CGRP activates NRF2 via non-electrophilic mechanisms, with organ-specific pathways and time-dependent effects on oxidative stress resistance.

This paper introduces an automated platform for azapeptide synthesis that overcomes synthetic challenges by using pre-activated building blocks and microwave-assisted synthesis, enabling efficient and scalable production of stabilized peptide therapeutics.

This study shows that vagus nerve stimulation reduces germinal center B cell responses by affecting CD4+ T cell-derived acetylcholine and its downstream effects on B cell survival and follicular dendritic cell function.

This study shows that both acute and chronic diving reflex activate NRF2 signaling, with acute exposure inducing stronger antioxidative gene expression than chronic exposure.

The paper shows that ultrasound neuromodulation of the spleen reduces experimental pulmonary hypertension by improving hemodynamics and reducing inflammation.

This study uses voltammetry in the spleen to measure real-time norepinephrine release during autonomic nerve stimulation and links it to anti-inflammatory effects.

This study shows that vagus nerve fascicles are organized by function and organ innervation, enabling targeted stimulation with reduced side effects.