David T. Rubin

The paper presents the Human Gut Cell Atlas v1.0, a unified reference of gut cell diversity, revealing how tissue structure influences cellular composition and enabling disease and organoid analysis.

This study shows that a regular chow diet, not microbial transplant, enables rapid gut microbiome recovery after antibiotics in mice, and that diet is essential for effective fecal microbiota transplant.

This study identifies histopathological and molecular features linked to J-pouch failure in IBD patients using single-cell spatial transcriptomics.

The paper identifies bacteria that conjugate GABA and tyramine to bile acids in the human gut and shows these conjugates are present in stool and J-pouch contents.

This study shows that Bacteroides fragilis from UC patients promotes colitis in genetically susceptible mice, suggesting a role for pathobionts in IBD.