Christopher R. Weber

The paper engineers a Clostridial consortium to study isoDCA's role in modulating intestinal inflammation and regulatory T cell induction.

The paper uses cryo-electron tomography to directly visualize paracellular claudin-15 pores in tight junctions, confirming their structure and spacing.

This study shows that pancreatic cancer cells in a nutrient-stressed tumor microenvironment develop drug tolerance, and identifies BCL-XL inhibition as a potential therapeutic strategy.

This study identifies histopathological and molecular features linked to J-pouch failure in IBD patients using single-cell spatial transcriptomics.

ATAT automates spatial transcriptomics analysis by aligning and traversing tissue samples using self-supervised learning, improving gene expression modeling without manual annotation.

This study shows that Bacteroides fragilis from UC patients promotes colitis in genetically susceptible mice, suggesting a role for pathobionts in IBD.