Meenal Datta

This study identifies SPHK2 as a therapeutic target in G3MB, showing that its inhibition restores anti-tumor immunity and improves survival in mouse models, with enhanced effects when combined with radiation.

This study shows that microgravity-grown GBM organoids exhibit enhanced transcriptomic, proteomic, and architectural features associated with worse patient outcomes compared to ground controls.

The paper shows mechanical compression causes neuronal apoptosis, synaptic loss, and glial inflammation in GBM models, revealing pathways for neuroprotection.

This study shows chronic compression transforms macrophages into a pro-tumor state, resembling glioma-associated macrophages, independent of tumor cell factors.

This study uses instant FLIM to show that mechanical compression of stromal cells in breast cancer models alters their metabolism, with distinct effects on fibroblasts and adipocytes, validated by transcriptomics and mitochondrial analysis.

This study shows macrophages generate mechanical stress in agarose gels and respond to environmental stiffness and cytokine signals.

This study simulates how brain tumor mechanical forces affect glymphatic transport in the brain parenchyma, showing increased stress and strain reduce CSF flow rates.

This study compares the viscoelastic properties of normal and glioblastoma brain cells under shear stress, finding no significant differences in their mechanical behavior.

The paper introduces a Mem-dELISA platform for ultrasensitive, dual-color detection of colocalized proteins on extracellular vesicles, demonstrating its application in cancer research.