Author

Karl F. Poncha

Baylor College of MedicineORCID 0000-0001-5750-227XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Assay:ChIP-seq· 1 Approach:deep learning· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Nicolas L. YoungiD· 3 shared Ali JazayeriiD· 1 shared Alyssa T. PaparellaiD· 1 shared B Rutledge Smith· 1 shared Bei GaoiD· 1 shared Bria GrahamiD· 1 shared Brian D. StrahliD· 1 shared Geoffrey FoxiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersBiochemistry

Nicolas L. YoungORCID

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3 papers

Recent·Most cited

Cell BiologyNature CommunicationsPeer-reviewedApr 1, 2026

TFEB degradation is regulated by an IKK/β-TrCP2 phosphorylation-ubiquitination cascade

Yan Xiong, Jaiprakash Sharma, Meggie N. Young…·Marco Sardiello

This study identifies an IKK/β-TrCP2 phosphorylation-ubiquitination cascade that regulates TFEB stability, independent of other regulators.

6 citationstop 4%

humanexperimental assay

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BiochemistryJournal of Proteome ResearchPeer-reviewedFeb 28, 2025

Normalized and Directional Interplay Scoring for the Interrogation of Proteoform Data

Karl F. Poncha, Alyssa T. Paparella, Nicolas L. Young

The paper introduces two new PTM crosstalk scores to analyze histone proteoform dynamics in mouse organs during aging and demonstrates their application using proteoform data.

2 citations

mouseproteomics

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BiochemistryJournal of Biological ChemistryPeer-reviewedJul 1, 2024

H3K18 & H3K23 acetylation directs establishment of MLL-mediated H3K4 methylation

Geoffrey Fox, Karl F. Poncha, B Rutledge Smith…·Kanishk Jain

The paper shows that H3K18 and H3K23 acetylation enhance MLL1-mediated H3K4 methylation, while other modifications are less affected by tail acetylation.

23 citations

ChIP-seqproteomics

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