Author

Kristal A. Rychlik

Johns Hopkins UniversityORCID 0000-0001-5766-0913Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Pharmacology & Toxicology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:statistical model· 2 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Assay:metabolomics· 1 Assay:proteomics· 1

Frequent Co-Authors

Emily J. IllingworthiD· 3 shared Fenna C.M. SilléiD· 3 shared Aakriti MathuriD· 2 shared Alexandra MaertensiD· 2 shared André KleensangiD· 2 shared Sylvia S. SancheziD· 2 shared Chloe M. KashiwagiiD· 1 shared Daniel A. Medina-CleghorniD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersPharmacology & Toxicology

Emily J. IllingworthORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Pharmacology & ToxicologyToxicologyPeer-reviewedFeb 10, 2026

Prenatal Arsenic Exposure and Gene Expression in Fetal Liver, Heart, Lung, and Placenta

Kristal A. Rychlik, Sylvia S. Sanchez, Chloe M. Kashiwagi…·Fenna C.M. Sillé

This study examines gene expression changes in fetal liver, heart, lung, and placenta after prenatal arsenic exposure in mice, identifying immune-related pathway alterations and reduced Gbp3 expression in female placentas.

DOI 10.1016/j.tox.2026.154420

mousebulk RNA-seq

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ImmunologybioRxivPreprintJul 14, 2025

Developmental Immunotoxicity of Low-dose Inorganic Arsenic Reprograms Macrophages Inducing Tumor-promoting Phenotypes

Emily J. Illingworth, Sylvia S. Sanchez, Kristal A. Rychlik…·Fenna C.M. Sillé

This study shows that low-dose inorganic arsenic exposure reprograms macrophage polarization, increasing tumor-promoting activity and altering immune responses in a sex-dependent manner.

DOI 10.1101/2025.07.14.663593

mouseproteomics

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Pharmacology & ToxicologyToxicologyPeer-reviewedJul 27, 2023

Transcriptomic Effects of Low-Dose Inorganic Arsenic Exposure on Murine Bone Marrow-Derived Macrophages.

Emily J. Illingworth, Kristal A. Rychlik, Alexandra Maertens, Fenna C.M. Sillé

This study examines how low-dose inorganic arsenic exposure affects gene expression in murine bone marrow-derived macrophages, revealing sex- and stimulation-dependent changes in immune-related pathways.

6 citations

mousebulk RNA-seq

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