Cosmos Yuqi Wang

The paper introduces an imaging-based pooled screening method to identify genetic perturbations and their effects on cell states and neighboring cells in intact tissues.

The paper investigates 3D-genome organization and transcription regulation in distinct cell types of the mouse brain, finding cell-type-specific nuclear architecture and chromatin compartmentalization correlated with transcriptional activity and MeCP2 regulation.

This study identifies a combinatorial splicing code in Neurexin-3 that regulates inhibitory synapse function through a trans-synaptic dystroglycan signaling loop.

The paper reveals a cis/trans-protein interaction network that organizes reciprocal dendro-dendritic synapses by compartmentalizing neurexin-based trans-synaptic complexes.