Bojing Blair Jia

The paper investigates 3D-genome organization and transcription regulation in distinct cell types of the mouse brain, finding cell-type-specific nuclear architecture and chromatin compartmentalization correlated with transcriptional activity and MeCP2 regulation.

SnapFISH identifies chromatin loops from multiplexed DNA FISH data with high sensitivity and accuracy in mouse embryonic stem cells.

This paper introduces a spatial genome aligner that reconstructs chromosome architectures from DNA-FISH data and identifies chromosome ploidies, revealing new insights into chromatin organization.