Lilach Sheiner

The paper uses crosslinking mass spectrometry to map protein interactions in Toxoplasma gondii, identifying novel components of essential complexes and revealing structural diversity in mitochondrial machinery.

This paper investigates the role of fatty acid elongases (FAE) in Toxoplasma gondii type II strains, showing their importance for virulence, persistence, and lipid metabolism under stress.

This study shows doxycycline inhibits apicoplast and mitochondrial translation in Plasmodium falciparum and Toxoplasma gondii, reducing protein abundance and mitochondrial complex IV activity.

This study screens purine nucleoside analogues against Toxoplasma gondii and identifies compounds with potent anti-toxoplasmic activity and high selectivity.

This study characterizes mitochondrial complex composition in Perkinsus marinus, revealing conserved divergent features shared with apicomplexan parasites.

This study identifies and characterizes the Toxoplasma gondii ABCB7 homolog, showing its essential role in cytosolic iron-sulfur cluster biogenesis and protein translation.

This study shows that Plasmodium falciparum complex III is essential for asexual stage survival and gametocyte maturation, supporting its role as a drug target.

This study determines the structure of a unique II2-III2-IV2 mitochondrial supercomplex from Perkinsus marinus using cryo-EM, revealing novel subunit arrangements and functional features.

This paper identifies TgUUT1 as a key pyrimidine salvage transporter in Toxoplasma gondii and demonstrates that 5F-uracil derivatives are potent antiparasitic agents with efficacy comparable to sulfadiazine.

The paper identifies a new Toxoplasma gondii mitochondrial ribosomal protein essential for mitochondrial translation through in silico screening and experimental validation.

This paper engineers Toxoplasma gondii to deliver therapeutic proteins to the CNS by fusing them to the parasite's secretory proteins, demonstrating potential for intracellular delivery of treatments for neurological disorders.