Raimond B. G. Ravelli

The paper identifies conserved regions in ESX-1 related proteins by mapping SNVs from MTB isolates onto protein structures, highlighting potential therapeutic targets.

This study uses human airway organoids to model tuberculosis infection, showing mycobacteria infect epithelial cells with low efficiency and the organoid microenvironment controls but does not eliminate the pathogen.

This paper introduces a device called VitroJet for automated cryo-EM sample preparation, which reduces waste and improves reproducibility by using pin-printing and jet vitrification.