Bouke Catherine de Jong

This paper evaluates thin-layer agar (TLA) for faster, accurate bedaquiline-susceptibility testing of Mycobacterium tuberculosis directly from sputum samples, achieving high sensitivity and reducing time to result.

The paper uses genomic data and phylodynamic models to show that Mycobacterium tuberculosis lineages have similar infectiousness durations but differ in onset timing, affecting transmission dynamics.

This study analyzes 665 Mycobacterium kansasii complex strains to identify unique and shared genomic signatures, revealing lineage splits, virulence factors, and drug resistance mechanisms.

The paper examines transmission rates of borderline and common rpoB mutations in MDR-TB isolates from Bangladesh, finding no difference in transmission clustering between mutation types.

The paper identifies conserved regions in ESX-1 related proteins by mapping SNVs from MTB isolates onto protein structures, highlighting potential therapeutic targets.

The paper identifies high within-lineage genomic diversity and gene content differences in Mycobacterium tuberculosis complex lineage 5 compared to H37Rv, affecting transmission analysis and suggesting the need for alternative reference genomes.

The paper analyzes genomes of Mycobacterium africanum strains to identify a new lineage and explore their evolutionary history and phylogeography.

The paper develops a tool to convert whole genome sequencing data into rifampicin-resistant tuberculosis diagnostic test results, enabling analysis of RR-TB burden across different data sources.

The paper compares the genomes of Mycobacterium africanum Lineage 5 and 6 from Ghana, finding genomic diversity and selection pressure differences suggesting distinct ecological niches.