Sjoerd Wanrooij

This study explores how oligonucleotide design affects G4 ligand-conjugated oligonucleotide binding and stabilization of G-quadruplex structures.

This study identifies redox-dependent dimerization of PolDIP2 and a conserved ApaG-domain motif critical for CHCHD2 interaction, revealing structural features governing its mitochondrial function.

The study shows the Y951N mutation in POLgamma impairs its ability to switch between DNA synthesis and degradation, causing mtDNA depletion without directly affecting polymerase or exonuclease activity.

This study shows ADP-bound mtHSP70 binds preferentially to GRPEL1 over GRPEL2, with structural insights into their functional differences.

This study shows that the AMPK activator A-769662 improves mitochondrial function and partially restores mtDNA levels in cells with mtDNA depletion.

Mirin prevents mtDNA breakage and immune response in MGME1-deficient cells through MRE11-independent mechanisms involving TOP3A and mtDNA replication termination.

The paper develops a method to selectively target and stabilize individual G4 DNA structures using ligand-conjugated oligonucleotides, demonstrating specificity without affecting off-target G4 formations.