Mara Mennuni

This study investigates the role of the CHCHD2-CHCHD10 protein complex in mitochondrial dysfunction and lipid homeostasis in mice, showing its importance in motor function and disease resistance.

This study investigates tissue-specific effects of TFAM and mtDNA copy number manipulation in mtDNA mutator mice, revealing both beneficial and detrimental outcomes depending on the tissue.

The paper shows that inhibiting mitochondrial DNA transcription in mice increases fatty acid oxidation, reducing obesity and liver fat while decreasing oxidative phosphorylation capacity.