Taolin Yuan

The paper shows that inhibiting mitochondrial DNA transcription in mice increases fatty acid oxidation, reducing obesity and liver fat while decreasing oxidative phosphorylation capacity.

The paper identifies two SIRT5 variants in mitochondrial disease patients that reduce protein stability and activity but not neuropathology, using biochemical and mouse model analyses.

OCRbayes is a Bayesian framework for analyzing Seahorse XF OCR data, accounting for complex data structures to improve statistical inference.