Xiaoqin Wei

The paper identifies an age-associated immune-poised state in human bronchial epithelial cells that mediates RSV resistance in adults by enhancing RIG-I-STAT3 signaling.

This study shows that prior respiratory viral infections like SARS-CoV-2 or influenza accelerate lung tumor growth by altering the immune environment and promoting a pro-tumor microenvironment.

This study identifies TCF4 as a critical regulator of alveolar macrophage stemness and shows that targeting TCF4 can mitigate post-viral lung disease and fibrosis.

This study compares single-cell RNA sequencing data from human and mouse PASC samples to identify IFN-γ as a driver of respiratory sequelae post COVID-19.

This study identifies dysregulated immune-epithelial progenitor interactions in post-viral lung sequelae and shows that targeting IFN-γ, TNF, or IL-1β improves alveolar regeneration and pulmonary function.