Jie Sun

The paper identifies an age-associated immune-poised state in human bronchial epithelial cells that mediates RSV resistance in adults by enhancing RIG-I-STAT3 signaling.

This study shows that prior respiratory viral infections like SARS-CoV-2 or influenza accelerate lung tumor growth by altering the immune environment and promoting a pro-tumor microenvironment.

This study identifies HIF-1α+ CD4 T cells as key coordinators of a tissue-resident immune network in the lung during infection and cancer.

This study identifies age-associated delays in immune resolution to respiratory viral infection by analyzing single-cell RNA sequencing and flow cytometry data from young and aged mice.

This study identifies TCF4 as a critical regulator of alveolar macrophage stemness and shows that targeting TCF4 can mitigate post-viral lung disease and fibrosis.

This study investigates respiratory IgA responses after SARS-CoV-2 infection, vaccination, or hybrid immunity, showing that mucosal booster vaccination enhances IgA and protective immunity.

The paper identifies distinct type 1 immune networks associated with varying severities of restrictive lung disease following COVID-19.

This study shows that Rag-GTPases regulate B cell metabolism and immunity by restraining TFEB/TFE3 to maintain mitochondrial fitness and support T-independent humoral immunity.

This study compares single-cell RNA sequencing data from human and mouse PASC samples to identify IFN-γ as a driver of respiratory sequelae post COVID-19.

This study identifies dysregulated immune-epithelial progenitor interactions in post-viral lung sequelae and shows that targeting IFN-γ, TNF, or IL-1β improves alveolar regeneration and pulmonary function.

This study shows that specific MHC class I molecules on brain endothelium regulate CD8 T cell activity and neuropathology in experimental cerebral malaria.

This study shows that inhibiting SCD1 reduces TFH cell activity and germinal center B cell responses, linking fatty acid metabolism to immune responses.