Khaled Machaca

This study identifies a novel rapid progesterone signaling mechanism in frogs that involves a dual coreceptor trafficking trap to induce meiosis.

The paper compares the ability of different Orai isoforms to promote NFAT activation and transcription, finding Orai1α and Orai1β are more potent than Orai2 and Orai3.

This study shows that activating membrane progesterone receptors improves glucose homeostasis and insulin sensitivity in obese mice through AMPK-dependent metabolic reprogramming.

This study uses single-cell RNA sequencing to show that SOCE blockers BTP2 and CM4620 reduce cytotoxicity in CD8 T cells and NK cells while preserving anti-inflammatory programs in CD4 Tregs.

This study outlines the architecture of Ca2+ tunneling, a Ca2+ signaling modality, and shows it is important for Cl- secretion in sweat glands.

This study identifies ABHD2 as an essential co-receptor for mPRβ to trigger meiosis via PLA2 activity in Xenopus oocytes.

The paper shows that ER-mitochondria contact sites expand during mitosis, enhancing Ca2+ coupling and mitochondrial activation to meet increased energy demands.