Marco W. Fraaije

This study investigates the evolutionary and mechanistic diversity of bacterial NDH-2s, revealing lineage-specific catalytic mechanisms and their implications for drug development.

The paper shows that protein agglomerates in E. coli regulate cytoplasmic rheology, with diffusion inversely correlating with amino acid metabolism protein abundance.

This study characterizes McrA, a flavin-dependent enzyme from Streptomyces lavendulae, showing it oxidizes mitomycin C to prevent its toxic effects.

The paper investigates how ligand-induced oligomer dissociation affects enzyme diffusion using mass photometry, finding substrate-induced dissociation in some enzymes and not others.