Madeleine E. Lemieux

The paper shows that selective inhibition of BRD4-BD2 promotes SPOP-mediated degradation of BRD4/BRD4-NUT in NUT carcinoma, leading to better therapeutic outcomes than pan-BET inhibition.

This study shows that circadian rhythms in glycolysis and cell cycle progression are essential for cardiomyocyte proliferation and heart regeneration in zebrafish.

The paper identifies prolonged innate and adaptive immune responses as critical for heart regeneration in surface fish, showing that inhibiting these responses impairs regeneration.

The paper identifies CCL19⁺ fibroblasts as a proliferative niche in chronic lymphocytic leukemia by analyzing single-cell RNA sequencing data and characterizing interactions within lymph nodes.

This study identifies EZH2 as a dependency in NUT carcinoma, showing that combining EZH2 and BET inhibitors synergistically blocks tumor growth and prolongs survival.

The paper presents a chromosome-level genome of surface fish Astyanax mexicanus and uses it to identify genetic factors contributing to trait evolution in cavefish populations.

This study shows BRD4 promotes cardiac fibrosis by dynamically targeting chromatin and activating gene expression in fibroblasts, revealing a signaling pathway involved in heart failure.