Jon Christopher Aster

The paper identifies CCL19⁺ fibroblasts as a proliferative niche in chronic lymphocytic leukemia by analyzing single-cell RNA sequencing data and characterizing interactions within lymph nodes.

This study identifies the structural requirements of MIB1 for ubiquitin transfer in Notch signaling, showing that RING3 is essential for catalytic activity and dimerization.

This study shows Notch1 activates transcription by releasing paused RNA Pol II without requiring chromatin accessibility changes.

This study tracks Notch and Delta interactions in real-time, showing 1:1 stoichiometry at synapses and NICD nuclear entry after 45 minutes, inhibited by signaling blockers.

This study maps the spatiotemporal dynamics of Notch2 signaling from membrane to nucleus after ligand activation, identifying key molecular events in signal transmission.

The paper investigates the differential requirements for MAML1 in Notch-dependent transcription at HES4 and DTX1, showing distinct functional roles of MAML1 regions and interactions with p300.