Author

Liang-Dong Lyu

Fudan UniversityORCID 0000-0001-6391-6030Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:bacteria (other)· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Assay:DNA methylation· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Guoping ZhaoiD· 1 shared Han Fu· 1 shared Han FuiD· 1 shared Jing ShiiD· 1 shared Liqiao Xu· 1 shared Ming-Zhi DengiD· 1 shared Mingyu GaniD· 1 shared Qian Song· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperMicrobiology

Guoping ZhaoORCID

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2 papers

Recent·Most cited

MicrobiologybioRxivPreprintOct 11, 2025

Molecular mechanism of the key dormancy regulator DosR-dependent transcription activation in Mycobacterium tuberculosis

Jing Shi, Zhenzhen Feng, Han Fu…·Wei Lin

This study determines the cryo-EM structure of the DosR-dependent transcriptional activation complex in Mtb and identifies its molecular mechanism for dormancy regulation.

DOI 10.1101/2025.10.11.681782

cryo-EMexperimental assay

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MicrobiologybioRxivPreprintOct 24, 2023

Mycobacterial DnaQ is an Alternative Proofreader Ensuring DNA Replication Fidelity

Ming-Zhi Deng, Qingyun Liu, Shu-Jun Cui…·Liang-Dong Lyu

This study shows that mycobacterial DnaQ acts as an alternative proofreader, working with the PHP domain to maintain DNA replication fidelity and prevent mutations.

DOI 10.1101/2023.10.24.563508

bacteria (other)DNA methylation

𝕏 PostBluesky