Chang Jiang

This study identifies a metabolic vulnerability in NRF2-hyperactive cancers where selenite induces cell death by disrupting mitochondrial function and redox balance.

The paper shows cancer cells in the lung take up cysteine and cystine efficiently, and the reduced tumor microenvironment supports their growth and resistance to oxidative stress.

This study shows that reduced hepatic phosphatidylcholine biosynthesis leads to copper deficiency, which promotes MASH through disrupted copper distribution and fibrogenesis.