Tripti Tamhane

This paper introduces a DNA-barcode labelled MHCII multimer method to detect antigen-specific CD4 T cells across large epitope libraries and identifies 12 novel HCV epitopes.

This study shows that Ag-Neo2/15 scaffolds expand antigen-specific T cells with enhanced cytotoxicity and reduced dysfunctionality compared to Ag-IL2/21 scaffolds.

The paper identifies HLA-specific depletion of CD8 T-cell responses to EBV and neuroantigens in MS patients, revealing immunophenotypic differences between MS and healthy donors.

This paper designs de novo pMHC binders using generative models to create T cell-based cancer therapeutics with high specificity and minimal cross-reactivity.

This study identifies antigen-specific CD8+ T-cell responses linked to disease severity in SARS-CoV-2 infection, showing functional impairment and recognition bias.

The paper identifies a concise set of 137 virus-specific CD8 T cell epitopes recognized by human T cells, with 84% showing prevalent reactivity and associations with effector and memory phenotypes.