Katherine A. Alexander

This study expands the HIF-2α proteomic interactome using TurboID proximity labeling, identifying 329 novel interactors and linking some to poor patient survival in breast cancer.

The paper identifies SWING regions as chromatin domains that mediate gene regulation through interactions with nuclear speckles and the lamina, showing their role in development and disease.

This study shows nuclear speckles vary in cancer, correlate with survival in kidney cancer, and are regulated by HIF-2 through speckle targeting motifs.

The paper compares genotoxic and non-genotoxic p53 activation in human fibroblasts, showing similar genome-wide binding and chromatin changes but distinct inflammatory gene expression patterns.