Ruofan Yu

This study expands the HIF-2α proteomic interactome using TurboID proximity labeling, identifying 329 novel interactors and linking some to poor patient survival in breast cancer.

The paper identifies SWING regions as chromatin domains that mediate gene regulation through interactions with nuclear speckles and the lamina, showing their role in development and disease.

This study shows nuclear speckles vary in cancer, correlate with survival in kidney cancer, and are regulated by HIF-2 through speckle targeting motifs.

The paper investigates the role of yeast EndoG (Nuc1) in preventing genome instability by degrading cytoplasmic DNA and regulating its transfer to the nucleus.

This study identifies CTCF and cohesin as essential for chromatin-nuclear speckle association, showing their role in gene inducibility and relevance to disease.

This study compares convolutional and capsule neural networks for classifying microfluidic images of dividing yeast cells, finding convolutional networks more accurate overall while capsule networks excel at specific categories.