Blanca Tardajos Ayllón

The paper creates a single-cell transcriptome atlas of human subcutaneous adipose tissue vascular cells, identifies sub-AdECs, and links their properties to metabolic disease.

Endothelial Twist1 drives partial and advanced endothelial-to-mesenchymal transition via PELP1 and AEBP1-COL4A1 signaling, increasing collagen and ACTA2+ cells to stabilize atherosclerotic plaques in male mice and human carotid arteries.

This study shows EPAS1 reduces atherosclerosis at disturbed flow sites by promoting endothelial fatty acid uptake and metabolism, which is suppressed in obesity through triglyceride-PHD3 pathway.