John T. Cunningham

This study shows that SLC25A3-mediated copper transport to mitochondria is essential for skeletal myoblast differentiation and survival of mature myotubes.

This study analyzes PRPS enzyme evolution across domains of life, identifying new classes and regulatory mechanisms through phylogenetic and biochemical approaches.

This study uses SEC-ICP-MS to assess copper allocation to cytochrome c oxidase and identifies key transporters involved in mitochondrial copper trafficking.

This study traces the evolutionary origins of mammalian PRPS genes and shows how their duplication and specialization enable functional multimeric complexes with regulatory features.

This study identifies PRPS2 as a key regulator of redox homeostasis in Myc-driven lymphomas, showing that its inactivation causes reductive stress and cell death.

This study shows copper drives metabolic remodeling and progression in clear cell renal cell carcinoma by coordinating bioenergy, biosynthesis, and redox homeostasis.