Author

Guido Pacini

Max Planck Institute for Molecular GeneticsORCID 0000-0001-6506-6949Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Cell Biology· 1 Genetics· 1 Genomics· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Approach:statistical model· 3 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Edda G. SchulziD· 2 shared Ilona Dunkel· 2 shared Abhishek Sampath KumariD· 1 shared Afrah Ghauri· 1 shared Alessandro AiutiiD· 1 shared Alex MurisoniD· 1 shared Alexander MeissneriD· 1 shared Alicia G. Aguilar-NavarroiD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersGenetics

Edda G. SchulzORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Cell BiologyThe Journal of Experimental MedicinePeer-reviewedDec 5, 2025

Molecular and phenotypic blueprint of the hematopoietic compartment reveals proliferation stress as a driver of age-associated human stem cell dysfunctions

Emanuele Lettera, Luca Basso Ricci, Edoardo Carsana…·Raffaella Di Micco

The paper analyzes HSPC aging across the lifespan, finding age-related epigenetic dysregulation and impaired response to proliferative stress, using xenotransplantation models.

11 citationstop 3%

humanbulk RNA-seq

𝕏 PostBluesky

GeneticsbioRxivPreprintAug 2, 2022

GATA transcription factors drive initial Xist upregulation after fertilization through direct activation of a distal enhancer element

Liat Ravid Lustig, Abhishek Sampath Kumar, Till Schwämmle…·Edda G. Schulz

This study identifies GATA transcription factors as essential for initiating Xist upregulation and X-chromosome inactivation in mouse embryos through direct activation of a distal enhancer.

3 citations

mousestatistical model

𝕏 PostBluesky

GenomicsbioRxivPreprintJul 20, 2020

Integrated analysis of Xist upregulation and gene silencing at the onset of random X-chromosome inactivation at high temporal and allelic resolution

Guido Pacini, Ilona Dunkel, Norbert Mages…·Edda G. Schulz

The paper uses allele-specific single-cell RNA-sequencing to study Xist upregulation and gene silencing during X-chromosome inactivation in mouse embryonic stem cells, identifying Nanog downregulation as a trigger and genetic variation's role in XCI.

1 citation

mousescRNA-seq

𝕏 PostBluesky