Pakavarin Louphrasitthiphol

The paper identifies distinct gene expression programs driven by MITF, TFEB, and TFE3 in melanoma, revealing their functional specialization in regulating differentiation, metabolism, and immune infiltration.

This study identifies lactucopicrin, a sesquiterpene lactone from chicory, as a dual modulator of NF-kB and AHR pathways with anti-inflammatory effects.

This study shows that glycogen storage and metabolic buffering suppress phenotype switching in melanoma, with low glycogen levels linked to invasion and poor survival.

The paper identifies DHRS3 as a lipid droplet protein that regulates melanoma cell state by modulating retinoid signaling.

This study shows ALDH1A3 and ACSS2 coordinate acetaldehyde-acetyl-CoA metabolism with histone acetylation in melanoma, contributing to transcriptional heterogeneity and drug resistance.

The paper shows that MITFLow melanoma cells uptake fatty acids from adipocytes, activating AXL and CAV1 to drive beta-catenin nuclear accumulation, promoting invasion.

This study shows that the transcription factor MITF interacts with the MRN complex to modulate the DNA damage response in melanoma, contributing to cancer predisposition.

The paper identifies TBX3 as a key regulator in pheomelanogenesis and melanoma predisposition through scRNA-seq analysis of RHC mouse models.