Colin R. Goding

This study shows BRN2 is essential for preserving melanocyte lineage integrity after ionizing radiation, but not for normal maintenance.

This study identifies BRN2 as a regulator of melanocyte stem cell resilience under genotoxic stress, showing its role in preventing irradiation-induced hair greying.

The paper identifies ciliary proteins that regulate melanogenesis in melanocytes and reveals moonlighting roles for Joubert Syndrome proteins in endolysosomal organization.

The paper identifies distinct gene expression programs driven by MITF, TFEB, and TFE3 in melanoma, revealing their functional specialization in regulating differentiation, metabolism, and immune infiltration.

The paper investigates the role of SETD6 in mediating BRD4 and MITF interactions and genomic occupancy in melanoma cells, revealing a chromatin complex that regulates gene expression.

This study shows that glycogen storage and metabolic buffering suppress phenotype switching in melanoma, with low glycogen levels linked to invasion and poor survival.

The paper identifies DHRS3 as a lipid droplet protein that regulates melanoma cell state by modulating retinoid signaling.

This study maps the acetyl lysine machinery interactions and identifies MAPKAPK2 as a factor contributing to resistance to BET bromodomain inhibitors in melanoma.

The paper shows that MITFLow melanoma cells uptake fatty acids from adipocytes, activating AXL and CAV1 to drive beta-catenin nuclear accumulation, promoting invasion.

This study shows that the transcription factor MITF interacts with the MRN complex to modulate the DNA damage response in melanoma, contributing to cancer predisposition.

The paper identifies TBX3 as a key regulator in pheomelanogenesis and melanoma predisposition through scRNA-seq analysis of RHC mouse models.