Javier E. Irazoqui

This study identifies acetylcholine signaling via muscarinic receptors as a driver of HLH-30/TFEB activation, enhancing infection resilience in C. elegans.

This study shows that loss of mitochondrial glutathione reductase and thioredoxin reductase in C. elegans causes growth, fertility, and muscle defects, activates a constitutive UPRmt, and alters mitochondrial morphology.

This study shows that S. aureus infection causes degeneration of nociceptive neurons in C. elegans, leading to impaired behavior and reduced neuronal function.

This study shows that activating the alpha7 nicotinic receptor in macrophages triggers TFEB nuclear translocation and a pro-inflammatory gene signature without cytokine release.

This study shows that a glucose-fed microbiota in C. elegans reduces lifespan and healthspan, increases intestinal permeability, and raises susceptibility to bacterial pathogens.

This study identifies cryptic virulence and protective roles of individual CeMbio bacteria in C. elegans, highlighting the importance of HLH-30/TFEB in host defense.