Romain Vuillefroy de Silly

This paper describes LimCORE, an automated system for CAR-T cell manufacturing that achieves comparable performance to existing methods while reducing operator time.

This study shows that PI-103 and samotolisib enhance CRISPR/Cas9-mediated TCR knockin efficiency in human T cells without affecting viability or phenotype.

This study shows that low pH impairs CD8+ T cell function by reducing IL-2 responsiveness, disrupting mTORC1 signaling, and altering c-Myc levels and amino acid metabolism.

This study shows that a variant of IL-2 (IL-2v) induces a stem-like, metabolically active T-cell state with improved therapeutic potential in adoptive cell therapy.