Isaac Crespo

The paper identifies pro-metastatic TAMs in breast cancer and develops a computational-experimental framework to predict and inhibit their activity through pathway analysis and drug screening.

This study shows that low pH impairs CD8+ T cell function by reducing IL-2 responsiveness, disrupting mTORC1 signaling, and altering c-Myc levels and amino acid metabolism.

This study shows that a variant of IL-2 (IL-2v) induces a stem-like, metabolically active T-cell state with improved therapeutic potential in adoptive cell therapy.