Author

Bili Seijo

Centre Hospitalier Universitaire VaudoisORCID 0000-0003-2479-6261Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:perturbation response prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

George CoukosiD· 2 shared Isaac CrespoiD· 2 shared Melita B. IrvingiD· 2 shared Romain Vuillefroy de SillyiD· 2 shared Cristina Jiménez‐LunaiD· 1 shared Elisabetta CribioliiD· 1 shared Galia MontalvoiD· 1 shared Helen Carrasco HopeiD· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCell Biology

George CoukosORCID

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2 papers

Recent·Most cited

Cell BiologyThe EMBO JournalPeer-reviewedSep 16, 2024

Acidity-induced dysfunction of CD8+ T cells is characterized by impaired IL-2 responsiveness and perturbations to mTORC1 signaling and c-Myc levels

Romain Vuillefroy de Silly, Laetitia Pericou, Bili Seijo…·Melita B. Irving

This study shows that low pH impairs CD8+ T cell function by reducing IL-2 responsiveness, disrupting mTORC1 signaling, and altering c-Myc levels and amino acid metabolism.

51 citationstop 2%

humanproteomics

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Systems BiologybioRxivPreprintMay 24, 2023

Transcriptional reprogramming by IL-2 variant generates metabolically active stem-like T cells

Yaquelin Ortiz-Miranda, María Masid, Cristina Jiménez‐Luna…·George Coukos

This study shows that a variant of IL-2 (IL-2v) induces a stem-like, metabolically active T-cell state with improved therapeutic potential in adoptive cell therapy.

2 citations

humanbulk RNA-seq

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