Sarah B. Worthan

This study shows how fluctuating environments shape genetic interactions in E. coli by selecting for mutations in transport genes that exhibit environment-dependent epistasis and improve fitness across feast and famine conditions.

This study shows that initial mutations can constrain adaptive diversification in structured environments, highlighting the role of genotype-by-environment interactions in evolutionary outcomes.

The paper identifies an Arg to His mutation in Rho that enables E. coli to adapt to fluctuating pH during starvation by altering transcription termination and pH homeostasis.

This study experimentally evolved E. coli populations under feast/famine cycles, finding high mutational parallelism and trade-offs between growth and survival traits.

This study shows that an uL22(K90D) ribosomal protein variant in E. coli confers macrolide resistance and alters gene expression related to acid resistance, catabolism, and biofilm formation.