Jonathan S. Marchant

This study uses immunolocalization and single-cell RNAseq to show TRPMPZQ expression in excitable cells and sensory structures across Schistosoma mansoni life stages, with reduced expression in PZQ-resistant strains.

TRPtracker aggregates TRPMPZQ variants and their PZQ sensitivity data to monitor resistance and support schistosomiasis control strategies.

The paper shows clonazepam activates TRPM8 ion channels, which may explain its efficacy in treating burning mouth disorder.

This study shows JPT2, an intrinsically disordered NAADP-binding protein, undergoes liquid-liquid phase separation, forming condensates that recruit components involved in NAADP-evoked Ca2+ signaling.

The paper uses population genomics and functional genetics to identify praziquantel resistance variants in Schistosoma mansoni.

The paper identifies a new flukicide, BZQ, effective against both Fasciola and Schistosoma species by targeting a conserved TRPMPZQ ion channel.

The paper identifies a transient receptor potential channel (Sm.TRPMPZQ) as the genetic basis for variation in praziquantel response in Schistosoma mansoni.