Author
Medical College of WisconsinORCID 0000-0003-0065-7160Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
Claudia M. Rohr, Frances Blow, Sang-Kyu Park…·Jonathan S. Marchant
This study uses immunolocalization and single-cell RNAseq to show TRPMPZQ expression in excitable cells and sensory structures across Schistosoma mansoni life stages, with reduced expression in PZQ-resistant strains.
Claudia M. Rohr, Sang-Kyu Park, Kelsilandia Aguiar-Martins…·Jonathan S. Marchant
TRPtracker aggregates TRPMPZQ variants and their PZQ sensitivity data to monitor resistance and support schistosomiasis control strategies.
Daniel J. Sprague, Sang-Kyu Park, Svenja Gramberg…·Jonathan S. Marchant
The paper identifies a new flukicide, BZQ, effective against both Fasciola and Schistosoma species by targeting a conserved TRPMPZQ ion channel.
Evgeny G. Chulkov, Claudia M. Rohr, Jonathan S. Marchant
This study identifies a cation current activated by praziquantel in Schistosoma mansoni neuronal tissue, matching the properties of TRPMPZQ.
Winka Le Clecʼh, Frédéric D. Chevalier, Ana Carolina Alves de Mattos…·Timothy J. C. Anderson
The paper identifies a transient receptor potential channel (Sm.TRPMPZQ) as the genetic basis for variation in praziquantel response in Schistosoma mansoni.