Matthew I. Hutchings

This study defines the OrrA regulon in Streptomyces venezuelae, showing it regulates sporulation and antibiotic production via WblA.

This paper shows that MtrAB in Streptomyces venezuelae senses osmotic stress via sucrose, activates ectoine production, and triggers sporulation through direct regulation of bldM and whiI.

The paper investigates redox control of antibiotic biosynthesis in Streptomyces formicae, showing that a redox-sensitive repressor senses oxygen to regulate formicamycin production.

This paper identifies CutRS as a two-component system in Streptomyces that senses secretion stress via cysteine residues and regulates antibiotic production in response to glucose.

The paper reports new aromatic polyketides called formicapyridines, shows how mutating a single gene increases their production, and identifies a non-catalytic role for ABM superfamily proteins in maintaining biosynthetic pathway fidelity.