Barrie M. Wilkinson

This study analyzes genomic changes in Streptomyces clavuligerus strains during domestication, showing how mutations and rearrangements enhance antibiotic production while reducing metabolic flexibility.

This study defines the OrrA regulon in Streptomyces venezuelae, showing it regulates sporulation and antibiotic production via WblA.

This paper shows that MtrAB in Streptomyces venezuelae senses osmotic stress via sucrose, activates ectoine production, and triggers sporulation through direct regulation of bldM and whiI.

This study identifies two pathogen-induced diterpenoid pathways in wheat that produce antimicrobial compounds, revealing organizational separation of diterpenoid-based chemical defenses.

The paper describes a new secondary chromosome, EEC1, in the Embleya genus, which is distinct from other secondary replicons and plays a key role in the genus' metabolism and evolution.

The paper discovers and characterizes biffamycin A, a novel glycopeptide antibiotic from Streptomyces albidoflavus, highlighting its antimycobacterial and antistaphylococcal activity.

The paper investigates redox control of antibiotic biosynthesis in Streptomyces formicae, showing that a redox-sensitive repressor senses oxygen to regulate formicamycin production.

This paper identifies CutRS as a two-component system in Streptomyces that senses secretion stress via cysteine residues and regulates antibiotic production in response to glucose.

The paper reports new aromatic polyketides called formicapyridines, shows how mutating a single gene increases their production, and identifies a non-catalytic role for ABM superfamily proteins in maintaining biosynthetic pathway fidelity.