Zhi Lin

This paper introduces EYClamp, a de novo designed enzyme for photo-proximity labeling of E3 ligase neighborhoods in live cells, identifying over 1,500 candidate neighbors for four E3 ligases.

The paper uses spatiotemporal photocatalytic proximity labeling to track dynamic EGFR interactomes both extracellularly and intracellularly upon EGF activation.

This paper designs a protein to bind naphthalenediimides and evaluates its ability to generate reactive species for proximity labeling.

This study engineers a minimal EDV for genome editing by removing viral components, showing improved efficiency and reduced size.

The paper introduces a multi-scale proximity labeling method using Eosin Y to map cell surface protein neighborhoods at varying resolutions and validates interactions of EGFR and CAR-T cell synapses.